Unwrapping Granulomas: Characterizing Lymphocyte Populations from Bronchoalveolar Lavage and Mediastinal Lymph Nodes from a Canadian Cohort with Sarcoidosis

Summary

Our project is focused on understanding the changes that occur in immune cells and why they are dysfunctional in lung samples from patients with sarcoidosis. We hope this will help us better understand sarcoidosis, which is a rare inflammatory condition that can affect the lungs and many other organs. We will analyze immune cells for their numbers and their metabolism found on washes of the lung, from lymph nodes in the lungs, and blood samples. With our analysis, the we hope to better understand why sarcoidosis occurs and why it progresses in some individuals. Better understanding of the disease will lead to development of targeted treatment options, and tools for physicians to better predict how sarcoidosis will behave in a patient.

Eligibility

Currently recruiting participants: Yes

Eligible ages: 18 to 90

Inclusion criteria:

You are eligible for this study if you are:
1) 18 years of age or older.
2) Referred to a lung specialist for a possible diagnosis of sarcoidosis
3) Undergoing bronchoscopy (camera test of the lung) for investigation of possible sarcoidosis.

Exclusion criteria:

You are not eligible for this study if:
1) You have had a lung infection within four weeks of initial assessment date.
2) You are or could be pregnant.
3) You have a chronic infection such as active tuberculosis, non-tuberculous mycobacteria, HIV.
4) You are younger than 18 years old.
5) You have a medical condition that would prohibit you from safely undergoing bronchoscopy.

Participate

Fill out the following form if you want to participate in this research

Method of contact

UCalgary Notice of Collection
The University of Calgary (UCalgary) respects your privacy and is committed to ensuring the privacy of all students, staff, and community members. Your personal information is being collected under the authority of section 4(c) of the Protection of Privacy Act (POPA). It will be collected, used and disclosed for the purposes outlined in UCalgary’s Notice of Collection, Use and Disclosure of Personal Information and managed in accordance with UCalgary’s Privacy Management Program. Your personal information may be input into automated systems to generate content or make decisions, recommendations, or predictions. If you have questions regarding this notice or UCalgary’s collection, use, or disclosure of your personal information, please contact accessandprivacy@ucalgary.ca.

Additional information

Contact information

Recruitment is available through physician referral to a specialist in Respiratory Medicine. Primary Investigator: Dr. Daniel Vis 403-956-2800 Daniel.vis@ucalgary.ca South Health Campus Pulmonary Sarcoidosis Clinic

Principal investigator:

Daniel Vis

Clinical trial:

No

REB-ID:

REB25-1033