Treatment Optimization Pillar
Project Theme: Innovation and Commercialization
The major objective of this project is to identify novel compounds that interfere with replication and translation of important pathogens including but not limited to multi-resistant Mycobacterium tuberculosis.
Why is This Important?
The WHO created a priority list of antibiotic-resistant bacteria to support drug discovery efforts in important areas. The ultimate aim of the proposed research is to identify novel classes of inhibitors against these pathogens.
- Can we apply knowledge in antiviral drug discovery to bacterial targets?
We will use biochemistry to study the molecular basis for drug action and resistance to antivirals. Primarily we will look into enzymes like polymerases or nucleases that depend on divalent metal ions. We will then use this knowledge and apply it to functionally equivalent targets in bacteria.
Leveraged Sources of Support
Knowledge & Technology Exchange and Exploitation
- New partnerships with the private sector
Highly Qualified Personnel
- 1 PhD student
- 1 MSc student
- 1 Research Associate