Treatment Optimization Pillar
Gut Innate Immunity Across Microbiome Differences During Infectious Colitis and Immunomodulatory Therapeutics in Pigs
Principal Investigator: Eduardo R Cobo, PhD
Co-Investigators: Andre Buret, PhD; Leluo Guan, PhD; Ben Willing, PhD
Trainnees: Anshu Babbar, PDF; Cristina Fodor, M.Sc. Candidate; Yi Lin Tan, M.Sc. Candidate
Project Theme: Innovation and Commercialization
Our aim is to develop immunomodulatory antimicrobials to alleviate and reduce gut pathogen colonization in swine dysentery (SD). Such approach is of interest in Canadian agriculture (livestock productivity and animal welfare) to reduce the use of antibiotics in food producing animals.
Why is This Important?
Diarrheic colitis by Brachyspira hyodysenteriae is a devastating disease in growing pigs. SD reduces pork productivity and is an animal welfare issue. There is emergence of antimicrobial-resistant SD bacteria.
Leveraged Sources of Support
- Operating grants and infrastructure at the UofC (VSRS) and UofC Departments (Immunology and Microbiome) leverage the MIF funds
Knowledge & Technology Exchange and Exploitation
- A multidisiplinary program with the industry and producers to develop novel therapeutic alternatives to reduce antibiotic use in the pork industry
Highly Qualified Personnel
- 1 PDF
- 1 PhD Student
- 2 Undergraduate Students
- DVM Students are involved in pig SD experiments and data analysis