Prevention of Transmission Pillar
Understanding the Epidemiology of Invasive StrepA in Alberta Leading to the Development of Novel Therapeutic and Prevention Strategies.
Project Key Words: Invasive StrepA
Principal Investigator: ; Gregory Tyrrell, PhD, FCCM, D(ABMM)
Co-investigator: Matthew Croxen, PhD, Michael Good, MD, PhD
We will develop a clear understanding of the epidemiology of invasive Group A streptococcal disease in Alberta. We will understand the circulating strains, their antibiotic resistance, their toxin profiles, and the populations most severly affected. This information will aid in laying the ground work for a vaccine trail in 2020.
Why is This Important?
This information is important in guiding a planned StrepA vaccine trail and in trailing new experimental therapies for invasive Group A streptococcal disease.
This work will provide the needed information to generate targeted tools such as specific antibodies against these StrepA proteins thereby potentially treating invasive StrepA disease.