Project Snapshot

Surveillance Pillar

Human Exposure to and Risk from Antimicrobial Resistant Campylobacter, Enterococcus and ESBL E. coli: A Farm-to-Fork Assessment

Project Key Words: Campylobacter, Enterococci, E. coli, Risk Assessment, Integrated Assessment Model

Principal Investigator: Simon Otto, PhD

Co-Investigator(s): Richard Reid-Smith, DVSc; Carolee Carson, PhD; Colleen Murphy, PhD; Ben Smith, MSc; Ainsley Otten, BEng; Nicholas Ashbolt, PhD; Tim McAllister, PhD; Rahat Zaheer, PhD; Sylvia Checkley, PhD; Scott McEwen, DVSc, DipACVP; Lynora Saxinger, CTropMed, MD, FRCPC; Eduardo Taboada, PhD; Doug Inglis, PhD

Trainees: Christine Neustaedter, BA; Dana Tschritter, BSc; Qiaozhi Li, PhD

Project Theme: Innovation and Commercialization

The Aim

The focus of this project is on  quantitative modeling strategies to understand the risk of AMR transmission through the food chain to people.

Why is this Important?

We must understand the magnitude of exposure for these foodborne AMR risks (Fluoroquinolone-resistant Campylobacter and ESBL E. coli) to design One Health antimicrobial stewardship approaches for veterinary and human medicine.


  1. New quantitative modeling tools to understand the exposure and risk of AMR transmission through the food chain to humans
  2. Understanding of the farm-to-fork pathway for AMR transmission, including potential interventions to reduce this transmission

Research Questions

  1. What is the human exposure to and risk of foodborne transmission of AMR from Campylobacter? (Fluoroquinolone, macrolide or tetracycline-resistance in poultry and beef cattle)
  2. What is the human exposure to foodborne transmission of other AMR from beef cattle? (Macrolide-resistant Enterococcus spp. & ESBL E. coli)

Our Approach

We will first conduct a scoping review on the risk factors for human infection with AMR Campylobacter. Integrative Assessment Models will be utilized as they are designed to deal with complex issues, providing a comprehensive mechanism for organising, and processing evidence and uncertainty. We will also use QMRAs as they can assess the effects of factors and interventions influencing the public health impacts of exposure to AMR Campylobacter from poultry.

Leveraged Sources of Support

  • PHAC
  • GRDI NRC1 + NRC2
  • UofA School of Public Health

Knowledge & Technology: Exchange and Exploitation

  • Identification of risk management interventions to curb the transmission of AMR through the foodchain.
  • Changes in veterinary antimicrobial prescribing practices.

Highly Qualified Personnel

  • 2 MSc Student (WP 3B)
  • 1 PhD Student (claimed in WP 3C)
  • 1 Research Associate