Biomarkers and Mild Behavioural Impairment (BAMBI)

Summary

This study enrolls community dwelling adults over the age of 40 for assessments of cognition, behaviour, function, quality of life, and caregiver stress, in association with biomarkers, at 18 month intervals. Participants attend with a study partner, and at each visit are given a series of questionnaires and tests. The overall visit is ~2.5 hours in duration. Biomarkers of inflammation and neurodegeneration are obtained via a participant blood draw and urine collection at each visit. Additionally, participants will be given a stool collection kit to take home which will be returned to the lab for gut microbiome analysis.

Eligibility

Currently recruiting participants: Yes

Eligible ages: 40 to 99

Accepts healthy participants: Yes

Inclusion criteria:

1. Females aged 40 or older or males aged 60 and older with normal cognition, subjective cognitive decline, mild cognitive impairment, mild AD dementia, or moderate AD dementia.
2. Study partner available who has known the participant for ≥5 years
3. Must be able to attend in-person visits at the Foothills Hospital in Calgary, AB.

Exclusion criteria:

1. Developmental disorders and neuropsychiatric conditions that would affect testing (e.g., autism, Huntington’s disease, schizophrenia, bipolar disorder)
2. Unable to provide informed consent
3. No study partner
4. Not fluent in English

Participate

Fill out the following form if you want to participate in this research

Method of contact

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Additional information

Contact information

Ramnik Brar

Principal investigator:

Zahinoor Ismail

Clinical trial:

No

REB-ID:

REB21-1463