Bone Turnover in Patients with Knee Osteoarthritis Prior to Knee Replacement Surgery


Do you or someone you know suffer from painful and swollen knees? A likely cause is osteoarthritis, a common joint disease that gets worse over time. Osteoarthritis is caused by decreased cushioning between the bones at a joint, causing them to rub together. Although it is quite common, not much is known about what the joint looks like before symptoms are felt or what happens to the bone structure around bone bruises commonly seen in osteoarthritis patients. We're hoping to solve the mystery by evaluating bone changes before surgery using X-ray and MRI images of knees with osteoarthritis.


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 45 to 90

Inclusion criteria:

Males and females with end-stage osteoarthritis of the knee who:
- are at least 45 years old
- are attending the Hip and Knee Clinic at Gulf Canada Square
- intend to undergo a knee replacement

Exclusion criteria:

- have had previous knee surgery which would have caused bone damage
- have a known blood borne illness (such as hepatitis B)
- pre-menopausal women


This study is not currently accepting expressions of interest via the website. Please see contact information below.

Additional information

Contact information

Recruitment is only by referral through the Hip and Knee Clinic at Gulf Canada Square.

Principal investigator:

Sarah Manske

Clinical trial: