CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome (CASA-POTS)


This study will evaluate high-salt compared to moderate-salt over a period of about 3 months. The purpose of this study is to see if increasing the amount of salt in the diet will reduce heart rate and symptoms in patients with POTS when compared to placebo (cellulose pill). To do this, we are conducting a randomized-clinical trial looking at a high-salt diet compared to a moderate-salt diet. This is a cross-over study, meaning that participants will do both the high-salt and moderate-salt components of the study. The study will have three in lab evaluations as well as online surveys.


Currently recruiting participants: No

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 60

Inclusion criteria:

-Physician Diagnosis of POTS
-Age 18-60 years old.
-Ability to attend the Calgary Autonomic Research Lab Clinic in Calgary
-Resident of Canada

Exclusion criteria:

-Participants who do not have a physician diagnosis of POTS
-Participants who are pregnant
-Participants who are taking fludrocortisone (Florinef)
-Participants who have received IV saline in the 2 months preceding the study or who plan to receive it during the course of the study


Sorry, this study is not currently accepting new participants.
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Additional information

Contact information

Principal investigator:

Satish Raj

Clinical trial: