PER DIEM Pilot Study


This research study provides an opportunity to test the value of extended heart monitoring for detecting silent atrial fibrillation in people who have had a recent ischemic stroke or TIA. Currently there are a number of different devices to monitor the heart for longer than the standard 24 hour Holter monitor. This study will compare the detection of atrial fibrillation with two extended cardiac monitoring technologies. The study will also evaluate whether or not the information gained from this additional heart monitoring will result in any changes to your current medication(s) based on your doctor’s recommendations.

The main goal of this research study is to determine whether an external or implanted loop recorder is better suited for diagnosing atrial fibrillation after a TIA/stroke.

The information we get from this study may help us to provide better treatments in the future for patients with a stroke or TIA.


Currently recruiting participants: No

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 100

Inclusion criteria:

1. Informed consent from the patient
2. Age ≥ 18 years
3. Diagnosis of the index event* made by a stroke specialist of an acute ischemic stroke or TIA occurring within the last 6 months. The event must be either:
i) arterial ischemic stroke confirmed by neuroimaging; or ii) transient ischemic attack with DWI positive lesion on MRI
4. The patient is expected to survive at least 6 months
5. At least one 12-lead ECG has already been obtained as part of the routine clinical post-stroke/TIA work-up, and no ECGs have shown any episodes of atrial fibrillation or atrial flutter
6. The patient is being actively investigated for the etiology of the stroke/TIA event and additional cardiac monitoring is desired to screen further for the possibility of occult paroxysmal atrial fibrillation/flutter

Exclusion criteria:

1. Previously documented atrial fibrillation/flutter.
2. Planned carotid endarterectomy or carotid artery stenting within 90 days.
3. Any condition for which there is already an indication for long term OAC.
4. Pacemaker or ICD device that would allow for detection of AF / atrial flutter.
5. Work-up for stroke that has already included extended (>7 days) external ECG.
6. Stroke and/or comorbid illness will prevent completion of planned follow-up assessments.


Sorry, this study is not currently accepting new participants.
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Additional information

Contact information

Hospital admission

Principal investigator:

Michael Hill

Clinical trial: