Does increased carbon dioxide (CO2) make patients with Postural Tachycardia Syndrome (POTS) feel better?

Summary

We are studying if increased carbon dioxide (CO2) can lower heart rate and reduces symptoms in patients with Postural Orthostatic Tachycardia Syndrome (POTS). Participants will perform Supine (lying down) to Stand test under different CO2 levels. We will monitor changes in heart rate and symptoms to determine which intervention is the most effective in minimizing symptoms and lowering heart rate.

Eligibility

Currently recruiting participants: Yes

Eligible ages: 18 to 60

Accepts healthy participants: Yes

Inclusion criteria:

1- POTS diagnosis or healthy volunteer
2- 18-60 years
3- Non-smoking
4- Able and willing to provide informed consent.
5- Able to travel to Libin Cardiovascular Institute of Alberta Autonomic Testing Lab at the University of Calgary, Calgary, AB.

Exclusion criteria:

1 - Other causes for increase in heart rate (eg. dehydration)
2 - Pregnant
3 - Inability to tolerate a mask during the study
4 - Require portable oxygen at rest or with exercise
5 - Heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
6 - Participants with severe anxiety

Participate

Fill out the following form if you want to participate in this research

Method of contact

UCalgary Notice of Collection
The University of Calgary (UCalgary) respects your privacy and is committed to ensuring the privacy of all students, staff, and community members. Your personal information is being collected under the authority of section 4(c) of the Protection of Privacy Act (POPA). It will be collected, used and disclosed for the purposes outlined in UCalgary’s Notice of Collection, Use and Disclosure of Personal Information and managed in accordance with UCalgary’s Privacy Management Program. Your personal information may be input into automated systems to generate content or make decisions, recommendations, or predictions. If you have questions regarding this notice or UCalgary’s collection, use, or disclosure of your personal information, please contact accessandprivacy@ucalgary.ca.

Additional information

Contact information

Student Investigator: Shaun Ranada Principal Investigator: Dr. Satish Raj

Principal investigator:

Satish Raj

Clinical trial:

Yes

REB-ID:

REB20-0135