Exploring the effects of O2 and CO2 on the autonomic nervous system


We are studying how breathing different levels of O2 and CO2 affects breathing, blood pressure and heart rate. We will compare healthy individuals to patients with disorders of their autonomic “automatic” nervous system. Breathing, blood pressure, heart rate, brain blood flow, and nervous system activity will be measured. Participants will perform different breathing tests while lying down and upright.


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 85

Accepts healthy participants: Yes

Inclusion criteria:

1- OH/POTS diagnosis OR Healthy volunteers
2- Over 18 years old
3- Non-smoker
4- Able and willing to provide informed consent.

Exclusion criteria:

1 - Inability to tolerate a mask during the study
3 - Requires portable oxygen at rest or with exercise
4 - Heart failure or severe lung disease who are unable to climb one flight of stairs due to shortness of breath.


Fill out the following form if you want to participate in this research

Method of contact

Additional information

Contact information

Dr. Jacquie Baker

Principal investigator:

Satish Raj

Clinical trial: