Non-immune role of immune cells in MS


This study aims to understand how certain immune cells (B cells) contribute to the development of MS. Traditionally it is thought that immune cells cause inflammation in the brain of MS patients through autoimmune mechanisms. We believe that B cells might additionally contribute to this disease in a completely novel way by promoting brain degeneration, much like what occurs in Alzheimer's and other neurodegenerative diseases.


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 80

Accepts healthy participants: Yes

Inclusion criteria:

1) any patient diagnosed with MS at any stage of the disease
2) healthy controls
3) patients with other neurodegenerative diseases that are unrelated to MS, like Alzheimer's and Parkinson's disease
4) other autoimmune diseases like lupus
5) cancer of the lymphatic system (lymphoma)

Exclusion criteria:

Patients receiving B cell-depleting medications (such as rituximab or ocrelizumab) are not eligible


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Method of contact

Additional information

Contact information

Dr. Peter K. Stys

Principal investigator:

Peter Stys

Clinical trial: