The purpose of this research study is to compare and better understand the structural heart differences and the blood flow between POTS patients and healthy individuals.

Potential participants will be recruited from the Calgary Autonomic Investigation & Management Clinic at the University of Calgary. We plan to enroll 30 POTS patients and 10 age- and sex-matched healthy controls


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 60

Accepts healthy participants: Yes

Inclusion criteria:

Following is the inclusion criteria for the study:
• POTS patients that have a pre-existing diagnosis of POTS (verified by investigators) and experience chest pains
• Healthy controls not diagnosed with POTS
• Age 18-60 years (inclusive; controls will be age-matched to enrolled POTS patients)
• Male and female (controls will be sex-matched to enrolled POTS patients)
• Left ventricular ejection fraction ≥50%
• Able and willing to provide informed consent

Following is the exclusion criteria for the study:
• Glomerular filtration rate <30 mL/min/1.73m2
• Significant cardiovascular, pulmonary, hepatic, or hematological disease by history or prior testing
• Hypertension, defined as blood pressure ≥145/95 mmHg off medications or requiring antihypertensive medication
• Somatization or severe anxiety symptoms
• Claustrophobia
• Highly trained athletes
• Pregnant women
• Smokers
• Known allergic or hypersensitivity reactions to gadolinium or adenosine
• Other factors which in the principal investigator’s opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule
• Unable or unwilling to provide informed consent


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Method of contact

Additional information

Contact information

Both are accepted as hospital admission and Physician refferal

Principal investigator:

Satish Raj

Clinical trial: