Treatment of Post-concussion syndrome with TMS: Using FNIRS as a biomarker of response

Summary

Treatment of Persistent Post-Concussion Syndrome with Repetitive Transcranial Magnetic Stimulation: Using Functional Near Infrared Spectroscopy as a Biomarker of Response

PURPOSE: To assess whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation approach, helps your brain to restore appropriate function, and whether functional near-infrared spectroscopy (fNIRS), a neuroimaging technology, can be used to determine your response to this treatment. A secondary question of whether blood biomarkers of inflammation and central nervous system injury change following TMS will also be explored.

WHO: Individuals diagnosed with post-concussion symptoms three months to five years post injury with or without clinical diagnosis of post-traumatic stress disorder.

WHAT: You will receive rTMS treatment for 4 weeks (Monday-Friday, 20 sessions total) at the Foothills Medical Center. Assessments include four questionnaire sessions and four fNIRS and blood collection sessions. Assessments will be scheduled for pre-TMS, post-TMS, 1-month post-TMS, and 3-months post-TMS.

BENEFIT: rTMS treatment may help improve symptoms of concussion such as headache frequency, intensity and duration, concentration, sleep and mood.