2023 Alex's Lemonade Stand 'R' Accelerated Grant

Eligibility

• Applicant institutions must be based in the United States or Canada. Applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.
• Applicants must have an MD, PhD, or MD/PhD (DO, MBBS or equivalent) and be within ten years of their first faculty appointment as an Assistant Professor at the time that their application is submitted.
• A minimum of 75% of the applicant’s time during the R Accelerated Award period must be allocated as protected time for all research activities. This percentage of time includes both R Accelerated Award activities and the applicant’s other research responsibilities.
• Applicants can be previous ‘A’ Awardees but cannot hold an ALSF ‘A’ Award and a R Accelerated Award concurrently.
• Applicants must have an independent award such as R01 (equivalent to $200,000 a year for 4 years) and must be within five years of notice of award of the R- award or equivalent. A letter of approval of award from the funding organization must be submitted with the application. There must be clear documentation of how scientific and budgetary overlap will be avoided.

Restrictions

• ALSF does not fund proposals for research utilizing human embryonic stem cells or non- human primates. Research with human induced pluripotent stem cells is permissible.
• Awards are not renewable.
• Projects focused on epidemiological aspects of pediatric cancer and/or cancer control are not eligible for the R Accelerated Award.
• Proposals focused on social determinants of health with an emphasis on oncologic outcomes (rather than psychosocial outcomes) are permitted.

Summary

The purpose of the R Accelerated Award Grant is to advance ALSF’s mission to find cures and better treatments for childhood cancers by providing support to scientists focused on pediatric oncology research. Applicants must have an original project that is not currently being funded with a clear focus on accelerating the discovery of more effective, less toxic therapy for childhood cancers. Research projects should address a testable hypothesis based on strong scientific rationale. Applicants must be recipients of a pediatric cancer research focused NIH R01 award or equivalent (e.g.: ACS etc.). Demonstration of continued commitment to pediatric cancer investigation as well as institutional support are critical components of a successful application. The R Accelerated Award is a four-year grant.

Scope of Proposal: Proposals must fall within the scope of Alex’s Lemonade Stand Foundation’s mission, focused on childhood cancers. Proposals with a sole/primary focus on patients >19 years of age will not be considered.

Budget: The requested budget should be in proportion to the scope of the proposed project and should be for direct costs of $800,000 USD or below over 4 years. A maximum of $200,000 in total costs may be requested per year. Refer to the Program Guidelines and Instructions more information on budgetary allowances and restrictions.

Resource and Data Sharing: Grant recipients are expected to share unique resources developed under this funding award, and as part of the application, applicants are required to submit a Resource Sharing Plan. Applicants should describe their track record of generating resources that are broadly re-used, the specific resources that will be generated in this proposed project, and the mechanisms by which those resources will be shared. To demonstrate a commitment to sharing that will be actualized, applicants should provide information in their sharing plan that clearly states the type of resource that will be shared, the method, characterization and timing of such sharing, and the anticipated resources (budget, personnel, etc.) required by the applicant and the resource user. Reviewers will consider the extent to which the dissemination of resources produced under the award will enhance or diminish the impact of the proposed work. For a full description and an example, see the Resource Sharing Form. For the full Resource Sharing Policy visit our Resources for Grant Applicants page.

Optional Childhood Cancer Data Lab Collaboration

Applicants may elect to work with the Childhood Cancer Data Lab at no cost to the investigator(s), as a part of this award. This is not required and is meant to serve as a benefit. If you are interested in collaborating with the Data Lab, please fill out this form (preferably 4 weeks before the Grant due date) and indicate your submission is associated with an Alex’s Lemonade Stand Foundation grant application. This resource does not have a cost associated with it and should not be included in the budget.

Overhead/Indirect Costs

Overhead/indirect costs are not allowed.

Application deadlines

RSO detailed review deadline

RSO final internal review deadline

Program application deadline

NOTE: Consult your Faculty Associate Dean (Research) (ADR) regarding Faculty-specific deadlines and submission processes.

Principal Investigators: Complete a Research Management System (RMS) record, including a copy of your complete application, and submit this for approvals in RMS.

Approvals: The University of Calgary requires that all funding applications be approved prior to submission. Approval requires signatures via either RMS or the RFAA Trainee form, in the following order:

• Principal Investigator
• Department Head
• Faculty ADR/Dean
• Research Services (on behalf of the Vice-President Research)

Read the Meaning of Grant Signatures policy to understand what your approval means. Please see the agency guidelines for details about which signatures are required on your application, as it may differ from internal requirements.

Late submissions: Late submissions will only be accepted in cases of medical or family emergencies, or other exceptional circumstances. If you submit your RMS record to Research Services after the internal deadline has passed, you must secure additional approvals. Please read: Late Applications Process.

Application Process

1. To start an application, navigate to the ALSF portal and losing (or complete your one-time registration and then login).
2. Complete your application according to Program Guidelines and Instructions.
3. Before submitting your application, initiate internal university approvals by completing a Pre-Award/Application record in RMS (https://my.rms.ucalgary.ca/). Attach a PDF of your completed application (along with any additional required attachments), and submit for approvals from your department head and/or faculty Associate Dean (Research). NOTE: When submitting in RMS, please ensure that you allow time for academic approvals prior to the Research Services Office internal review deadline of 12:00pm MT, May 9, 2023.
4. Once these approvals are obtained, RMS will automatically forward the Application record to Research Services for institutional review and approval.
5. Research Services will review, provide feedback (by email) if necessary, and will provide the institutional approval. If digital or wet-ink signatures are required, we will provide the capping institutional signature and will advise when ready.
6. A fully approved Application, including any supplementary documentation, must be submitted via the ALSF portal by 6:00pm, May 12, 2023.