2023 Burroughs Wellcome Fund's Next Gen Pregnancy Initiative

Eligibility

Postdoctoral fellows nearing transition to independent investigator status are welcome to contact program staff directly at ngp@bwfund.org about their planned proposal, competitiveness for the award, transfer to a new institution, and other questions that may arise.

• Postdoctoral fellows nearing their transition to independent investigator status through senior established investigators are eligible to apply.
• Proposals should address the biomedical causes and molecular mechanisms underlying adverse pregnancies and their outcomes including but not limited to peri-implantational events, placentation, fetal determinants, fetal-maternal immune responses, biological basis for racial-ethnic disparities, mechanisms relating preterm birth to other adverse pregnancy outcomes, biology of normal labor, genomics, evolutionary influences, maternal complications and other approaches. Proposals seeking to identify biomarkers predicting preterm birth are welcome.
• Citizens and non-citizen permanent and temporary residents of the U.S. and Canada who are legally qualified to work in the U.S. or Canada are eligible.
• Temporary Canadian residents must hold a valid Canadian visa (Study Permit, C-43, C-44, C-10, or C-20 work permits/visas).
• If a grant is awarded and your visa does not allow for such a stay, BWF may terminate the grant. BWF will not intercede on behalf of non-citizens whose stay in the U.S. or Canada falls out of visa compliance.
• Proposals can be submitted by individual investigators or research teams designating a contact principal investigator. At least one member of the team must have training and expertise outside the traditional areas of reproductive science.
• BWF is also interested in Preterm Birth Risk Stratification using artificial intelligence and machine learning.
• Proposals that cross institutional boundaries (partnerships between multiple universities or collaborations within larger universities) are welcomed.
• Current or active BWF preterm birth grant or next generation pregnancy award recipients are not eligible to reapply.
• Former BWF preterm birth or next generation pregnancy award recipients whose grant has been completed may reapply for another award provided the proposal submitted is a substantially different proposal (must not be a continuation or slight modification of previous work). The principal investigator must demonstrate successful outcomes and highlight significant achievements from the earlier award.

Summary

Growing evidence suggests the interrelatedness of the duration of pregnancy, fetal growth, and adverse pregnancy outcomes such as preterm birth, preeclampsia, intrauterine growth restriction, stillbirth, and maternal medical complications including maternal mortality. Other areas of interest are climate change and environmental impact on pregnancy, complications associated with ART, and epigenome-wide association studies. We have expanded the scope of this award mechanism to capture these and other pregnancy outcomes as we believe they will be mutually informative and accelerate discovery. 

The initiative is designed to stimulate both creative individual scientists and multi-investigator teams to approach healthy and adverse pregnancy outcomes using creative basic and translational scientific research methods. The formation of new connections between reproductive scientists and investigators who are involved in other areas is particularly encouraged. Postdoctoral fellows nearing their transition to independent investigator status through senior established investigators are encouraged to apply.

Molecular and computational approaches such as genetics/ genomics, immunology, microbiology, evolutionary biology, mathematics, engineering, and other basic sciences hold enormous potential for new insights independently or in conjunction with more traditional areas of parturition research such as maternal-fetal medicine, obstetrics, and pediatrics. We encourage applications seeking actionable therapeutic interventions, novel diagnostics, and device development for real time data capture, and particularly those investigating mechanisms of racial disparities in pregnancy outcomes.

Up to seven (7) research grants will be awarded. Research grants will provide $500,000 over a four-year period ($125,000 per year) and are expected to begin June 1, 2024.

BWF-NGPI-RFP-2024_v3.pdf

Overhead

Indirect costs may not be charged against the awards. Institutional overhead may not be charged against BWF grants.

Application deadlines

RSO detailed review deadline

RSO final internal review deadline

Program application deadline

NOTE: Consult your Faculty Associate Dean (Research) (ADR) regarding Faculty-specific deadlines and submission processes.

Principal Investigators: Complete a Research Management System (RMS) record, including a copy of your complete application, and submit this for approvals in RMS.

Postdocs, students, and trainees: For fellowships and externally-sponsored research training awards or opportunities, you must complete the Research Funding Application Approval (RFAA) Trainee PDF form, and submit it, along with a complete copy of the application, to Research Services at rsotrainee@ucalgary.ca. Trainees should not use RMS at this time.

Approvals: The University of Calgary requires that all funding applications be approved prior to submission. Approval requires signatures via either RMS or the RFAA Trainee form, in the following order:

• Principal Investigator
• Department Head
• Faculty ADR/Dean
• Research Services (on behalf of the Vice-President Research)

Read the Meaning of Grant Signatures policy to understand what your approval means. Please see the agency guidelines for details about which signatures are required on your application, as it may differ from internal requirements.

Late submissions: Late submissions will only be accepted in cases of medical or family emergencies, or other exceptional circumstances. If you submit your RMS record to Research Services after the internal deadline has passed, you must secure additional approvals. Please read: Late Applications Process.

Please contact Daniel Baroff at dbaroff@bwfund.org.