THE “HEAD START 4” PROTOCOL- NEWLY DIAGNOSED CHILDREN (LESS THAN 10 YEARS OLD) WITH MEDULLOBLASTOMA AND OTHER CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS: CLINICAL AND MOLECULAR RISK-TAILORED INTENSIVE AND COMPRESSED INDUCTION CHEMOTHERAPY FOLLOWED BY

Summary

Doctors would like to look at tumor tissue and blood samples from patients with brain tumors to learn more about childhood tumors. In the future, the information they learn may help to find out better ways to find tumors early, prevent tumors, and develop better therapies with fewer side effects.

This research study has two parts. The first part of the study is called Induction. During induction, you will be given either 3 cycles or 5 cycles of chemotherapy. You will also have a procedure performed called leukapheresis in which some of your own blood cells are collected and stored for later use.

The second part of the research study is called Consolidation. Before the start of Consolidation, you will need to finish the Induction part. You will be asked to sign another assent form if you go on to the Consolidation.