How do your hormones affect your joints?


We want to understand how female hormones affect the knee in people with and without conditions that cause loose joints.

The clinical conditions we are interested in studying are Hypermobility Spectrum Disorders (HSD) and hypermobile Ehlers-Danlos Syndrome (hEDS).

We also want to compare our findings to people with no history of these conditions.


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Eligible ages: 18 to 35

Accepts healthy participants: Yes

Inclusion criteria:

1. Age 18 - 35
2. Female sex
3. Regular menstrual cycles (every 25 - 31 days for at least the past 1 year)

We are looking for people either with a diagnosis of Hypermobile Spectrum Disorders or hypermobile Ehlers-Danlos Syndrome AND for people who are otherwise healthy to compare to

Exclusion criteria:

1. Estrogen or progesterone use (oral, transdermal, depo, vaginal) in the last 6 months
2. Testosterone use (oral, intramuscular, transdermal) in the last 12 months
3. Corticosteroid use (oral, intramuscular, intravenous) in the last 12 months
4. Pregnant within the last 12 months
5. Currently breastfeeding.
6. Previous right knee injury
7. Other connective tissue disorder (i.e. rheumatoid arthritis, Marfan syndrome, Loeys-Dietz syndrome, Down syndrome, etc.)
8. Use a wheelchair for day-to-day mobility


Fill out the following form if you want to participate in this research

Method of contact

Additional information

Contact information

Please contact our research team by email.

Principal investigator:

Ranita Manocha

Clinical trial: