RUNX1 Early Career Investigator Program

Eligibility

• Applicants must have an MD, PhD, or MD/PhD (DO, MBBS or equivalent).
• Applicants must have research experience working in, and a deep understanding of, normal or malignant hematopoiesis and/or immunology.
• Applicants must be within five years of their first faculty appointment as an Assistant Professor or equivalent tenure-track position. If at the Instructor level, the applicant must submit a letter of support from their mentor at the sponsoring institution.
• Associate and Full Professors are not eligible.
• A minimum of 75% of the applicant’s time during the award period must be allocated as protected time for all research activities (includes both activities on this grant and the applicant’s other research responsibilities).
• Applicants may have research grants from other funding sources during the award period, but there must be clear documentation of mechanisms to avoid scientific and budgetary overlap.
• Applicant institutions must be based in the United States or Canada; however, applicants need not be United States citizens.
• Funds must be granted to non-profit institutions or organizations.

Summary

The objective of the RUNX1 Early Career Investigator Program is to promote the establishment of a new generation of basic and translational scientists interested in tackling inherited hematologic malignancy predisposition disorders with a focus on RUNX1-familial platelet disorder. The RUNX1 Early Career Investigator grant is designed to fund research investigating strategies that will lead to the development of therapies that will prevent the transition from pre-malignancy to overt hematologic malignancy in patients with RUNX1-FPD.

The RUNX1 Research Program and ALSF host an annual scientific meeting that brings together grant recipients and other scientists. Grant recipients are expected to present their progress as part of the annual review. 

Submission Process

All applications are submitted through the Research Management System (RMS) to initiate internal approvals. Please note that when the RMS record finally reaches Research Services by the internal deadline, it should contain all the relevant Department and Faculty approvals. Please allow additional time for these approval steps. Late applications will only be accepted in cases of medical or family emergencies or other exceptional circumstances. If you submit your RMS record to Research Services after the internal deadline has passed, you will need to secure additional late approvals from your Faculty Associate Dean (Research) and the Executive Director, Research Services. Training resources are available on the RMS website.

1. Complete the full application according to the agency's guidelines.
2. To initiate internal approvals, complete the Pre-Award/Letter of Intent record in RMS, attach your completed application, and submit for approvals from your Department Head and faculty Associate Dean (Research).  Important: When submitting in RMS, please ensure that you allow time for academic approvals prior to the Research Services review deadline of December 16, 2022 at 12:00 pm. Please also note that approvers do not routinely receive notifications that an LOI is awaiting their approval. We suggest that you reach out to your approvers to let them know you have submitted an application for their review.
3. Once these approvals are obtained, RMS will automatically forward the application record to Research Services for institutional review and approval.
4. Research Services will review, provide feedback (by email) if necessary, and secure the institutional approval. If digital or wet-ink signatures are required, we will provide the capping institutional signature and will advise when ready.
5. The applicant must submit the application to the agency by December 21, 2022 at 8:00 pm (ET) via the ALSF online portal (https://alsfapps.force.com/).

Resources

• ALSF Resources for Grant Applicants
• 2023 RUNX1 Early Career Investigator Grant Guidelines

Relevant Documents

2023_runx1_early_career_investigator_grant_guidelines.pdf

Application deadlines

RSO final internal review deadline

Program application deadline

NOTE: Consult your Faculty Associate Dean (Research) (ADR) regarding Faculty-specific deadlines and submission processes.

Principal Investigators: Complete a Research Management System (RMS) record, including a copy of your complete application, and submit this for approvals in RMS.

Postdocs, students, and trainees: For fellowships and externally-sponsored research training awards or opportunities, you must complete the Research Funding Application Approval (RFAA) Trainee PDF form, and submit it, along with a complete copy of the application, to Research Services at rsotrainee@ucalgary.ca. Trainees should not use RMS at this time.

Approvals: The University of Calgary requires that all funding applications be approved prior to submission. Approval requires signatures via either RMS or the RFAA Trainee form, in the following order:

• Principal Investigator
• Department Head
• Faculty ADR/Dean
• Research Services (on behalf of the Vice-President Research)

Read the Meaning of Grant Signatures policy to understand what your approval means. Please see the agency guidelines for details about which signatures are required on your application, as it may differ from internal requirements.

Late submissions: Late submissions will only be accepted in cases of medical or family emergencies, or other exceptional circumstances. If you submit your RMS record to Research Services after the internal deadline has passed, you must secure additional approvals. Please read: Late Applications Process.

• If an applicant would like to work with the Childhood Cancer Data Lab, requests to collaborate must be submitted not later than 4 weeks before the grant application deadline.
• One resubmission of a full application previously reviewed by RRP/ALSF's Review Board is permitted.
• RRP/ALSF does not fund proposals for research utilizing human embryonic stem cells or non-human primates. Research with human induced pluripotent stem cells is permissible.
• The RUNX1 Early Career Investigator Grant is not transferable to another investigator.