Bicuspid Aortopathy and Aortic Flow


Bicuspid aortic valve disease is a common congenital heart defect that can cause the aorta to enlarge and weaken ( aneurysms), leading to possible rupture. The mechanisms that underlie this weakening process are poorly understood. Evidence suggest that blood flow in the aorta may play a role. The purpose of this study is to better understand how blood flow influences aortic aneurysms. Patients who are going for surgery to have their aorta resected would have an MRI ( with special images) prior to surgery and tissue samples would be taken from the resected aorta during surgery.
It is the hope of this study to advance the knowledge of the role of blood flow on aortic tissue function in both bicuspid and tricuspid aortic valves with enlarged aortas; providing new tools to determine best treatment strategies.


Currently recruiting participants: Yes

Eligible ages: 18 to 90

Inclusion criteria:

- 18 years of age
-stable congenital Bicuspid aortic valves (BAV) being assessed for aortic resection
-stable congenital Tricuspid aortic valves (TAV) being assessed for aortic resection
- able to comprehend and provide consent in English

Exclusion criteria:

- Previous cardiac surgery or other surgery done for aortic disease
- contraindication for MRI ( ie: metal in body, implanted medical device, poor kidney function)
- aortic dissection ( splitting of vessel wall)
- women who are pregnant or may become pregnant


Fill out the following form if you want to participate in this research

Method of contact

Additional information

Contact information

Darlene Ramadan Study Coordinator Ph: 403-210-7356 /

Principal investigator:

Paul Fedak

Clinical trial: