Monogenic Lupus Study


Very little is known about the role of genetics in the pathogenesis of systemic lupus erythematosus (SLE). SLE is a life-threatening, chronic, autoimmune disease where the immune system attacks healthy tissues of the body, affecting the joints, skin, kidneys, blood cells, heart, and lungs. We are interested in enrolling children who are suspected to have monogenic lupus and their families to determine if certain genes are responsible for this disease. To investigate this, demographic and laboratory diagnostic imaging are collected during routine visits. In addition, blood or saliva samples will be obtained and DNA sequencing will identify the genes that may be associated with lupus.


Currently recruiting participants: Yes

Eligible gender: Male, Female, Transgender, Other

Inclusion criteria:

1) Children with young-onset (<10y) SLE and
2) Families with multiple affected members with SLE.
3) Able to read, write, and speak English.

Exclusion criteria:

Individuals and families who are not suspected to have a monogenic lupus.


This study is not currently accepting expressions of interest via the website. Please see contact information below.

Additional information

Contact information

Recruitment for this study is only through referral.

Principal investigator:

Marinka Twilt

Clinical trial: