The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis (OPT-JIA)

Summary

Far too many kids and families live in dread over the weekly nausea and vomiting caused by methotrexate - a medicine that controls joint swelling in Juvenile Arthritis patients. If
methotrexate is not tolerated, expensive alternative biological medications may be started. This registry-based pragmatic randomized controlled trial will evaluate if routine
premedication with the anti-emetic drug Ondansetron, reduces nausea and vomiting and increases the proportion of children able to continue methotrexate. By preventing nausea
before it starts, we hope to give kids and families a better quality of life and see a more cost-effective use of medication.