CCS Breakthrough Teams Grants - Transforming the Future of Metastatic Cancer

Eligibility

A Principal Investigator must hold a firm academic position (as a primary appointment) which allows the individual to engage in independent research activities for the duration of the project and includes the ability to supervise trainees and publish research results. A researcher designated as the Principal Investigator must be based in, or formally affiliated with, an eligible Canadian Host Institution such as a university, research institute or health care agency.

Graduate students, postdoctoral fellows, research associates (who are not independent investigators), Adjunct Professors or Status only appointments (except where they hold a firm academic position at another Canadian institution), technical support staff, or investigators based outside of Canada are not eligible to be a Principal Investigator (see below for Research Training Award eligibility). Where there is uncertainty as to the eligibility of an individual due to their appointment/title, CCS encourages applicants to reach out for clarification. Both the Principal Investigator and executive authorities of the Host Institution are required to agree to the terms of the Host Institution/Canadian Cancer Society Agreement included as part of the application, thereby acknowledging and agreeing to all the responsibilities and obligations outlined in that Agreement.

The person named as the PI remains the PI on a grant for the duration of the grant unless given express permission by the Canadian Cancer Society.

For this competition there is a limit of one application per Principal Investigator or Co-Principal Investigator. Please review CCS’s eligibility and requirements section prior to composing the research team. 

Teams will be expected to:

• Be drawn from at least 3 Canadian provinces, (with international collaborations outside of Canada encouraged where expertise is essential).
• Be multi-disciplinary in composition (research pillar, scientific/clinical focus, discipline), to stimulate diverse approaches to addressing the research question, including how a potential solution could be administered equitably across Canada. 
• Include, as an integral part of the team, clinical and other health professionals, patient partners/people with lived experience (termed patients/survivors/caregivers, or PSCs), and knowledge users (such as policy specialists), whose experience and expertise will lend valuable insights to the development and implementation of the project.
• Include at least one early career investigator as a Co-Principal Investigator, and at least 3 trainees at the Master’s, PhD, or Postdoctoral levels – who will be provided with specific training and mentorship (by the team and CCS) throughout the duration of the grant.

Summary

The intent of the CCS Breakthrough Team Grants model is to bring together passionate and talented teams of scientists, clinicians, patient partners, and knowledge users from across disciplines to work synergistically and ‘think big’ to address important gaps in cancer research that will be transformational for people affected by the disease. 

The primary scientific objectives for this Breakthrough Team Grants program are two fold (and intended to be represented by at least 2 funded Breakthrough Teams):

Theme 1: To develop a better understanding of the biology of and mechanisms associated with cancer cell dormancy, including research that

• Investigates different models of dormancy such as angiogenic, immune-mediated, and cellular dormancy.
• Delineates the mechanisms behind why certain types/subtypes of cancer are more prone to dormancy.
• Explores the individual (human or tumour) factors (genetic, molecular, etc.) that lead some to develop metastatic disease while others do not.
• Explores the role of the host immune system in regulating dormancy.
• Explores a potential role for the human microbiome in tumour dormancy.
• Develops (and utilizes) new, physiologically relevant model systems that accurately represent dormancy in human cancers.
• Could result in interventions that can prevent the onset of metastatic disease.

Cancer cell dormancy remains an understudied and inadequately understood phenomenon. This funding opportunity attempts to change this. The research proposed should have a strong potential to lead to clinical application, but the primary focus should be on developing a more thorough understanding of dormancy that will inform all future research in this area.

Theme 2: To better support people living with advanced or metastatic disease throughout the course of their disease, including research that

• Examines interdisciplinary prevention/management of symptoms and chronic conditions (including non-pharmacological management).
• Seeks to provide improved psychosocial support.
• Seeks to develop integrated and appropriate palliative care.
• Improves support for caregivers.
• Considers longitudinal studies to provide a clearer picture of the unique needs of people living with long-term metastatic disease (particularly as they relate to patient-reported outcomes (PROs), or that could identify factors associated with longer-term survival of people diagnosed with metastatic disease.
• Seeks to better coordinate and deliver complex care.
• Considers equitable access to anticipated project outcomes from the outset.

The overarching goal of this Breakthrough Team Grants program is to catalyze collaborative and innovative research initiatives aimed at fundamentally transforming our understanding of cancer metastasis and enhancing support for those living with advanced or metastatic disease, ultimately leading to improved quality of life and extended survival for those affected by cancer.

SUBMISSION INSTRUCTIONS

LOI:

1. Complete LOI application on the CCS EGrAMS system
2. In RMS, start a new pre-award/Letter of Intent record. Complete the form and upload a copy of your final and complete LOI application to the RMS Application record, and submit for academic approvals.  Please ensure that you allow enough time for academic approvals prior to the Research Services (RSO) final internal deadline of NOON, June 24, 2024.
3. RMS will notify you that institutional approval has been provided. If an institutional signature is required, RSO will provide this. You may now submit on or before June 27, 2024 at 3:00PM Mountain time.

Full Application:

1. Complete Full Application on the CCS EGrAMS application system and print preview or save a pdf copy.
2. To initiate internal approvals, complete the Pre-Award/Application record in RMS (https://research.ucalgary.ca/conduct-research/additional-resources/resea...), attach the pdf version of your completed Application, and submit for approvals from your department head and/or faculty Associate Dean (Research). *Important: when submitting in RMS, please ensure that you allow time for academic approvals prior to the Research Services review deadline of 12:00pm on October 10, 2024
3. Once these approvals are obtained, RMS will automatically forward the Application record to Research Services for institutional review and approval.
4. Research Services will review, provide feedback (by email) if necessary, and will provide the institutional approval. If digital or wet-ink signatures are required, we will provide the capping institutional signature and will advise when ready.
5. Full Applications, including any supplementary documentation, should be submitted to the agency via the portal on October 15, 2024 by 3:00PM Mountain Time

Overhead

Not applicable

Pre-application deadlines

RSO internal deadline

Pre-application program deadline

Application deadlines

RSO final internal review deadline

Program application deadline

NOTE: Consult your Faculty Associate Dean (Research) (ADR) regarding Faculty-specific deadlines and submission processes.

Principal Investigators: Complete a Research Management System (RMS) record, including a copy of your complete application, and submit this for approvals in RMS.

Postdocs, students, and trainees: For fellowships and externally-sponsored research training awards or opportunities, you must complete the Research Funding Application Approval (RFAA) Trainee PDF form, and submit it, along with a complete copy of the application, to Research Services at rsotrainee@ucalgary.ca. Trainees should not use RMS at this time.

Approvals: The University of Calgary requires that all funding applications be approved prior to submission. Approval requires signatures via either RMS or the RFAA Trainee form, in the following order:

• Principal Investigator
• Department Head
• Faculty ADR/Dean
• Research Services (on behalf of the Vice-President Research)

Read the Meaning of Grant Signatures policy to understand what your approval means. Please see the agency guidelines for details about which signatures are required on your application, as it may differ from internal requirements.

Late submissions: Late submissions will only be accepted in cases of medical or family emergencies, or other exceptional circumstances. If you submit your RMS record to Research Services after the internal deadline has passed, you must secure additional approvals. Please read: Late Applications Process.

RESOURCES 

Support for projects involving Indigenous Research: 

Support with the development of your grant application is available through the Indigenous Research Support Team (IRST). Applicants can reach out by email to IRST at IRST@ucalgary.ca in advance of the RSO internal deadline. For more information about IRST, please visit the IRST webpage. 

Support for Knowledge Engagement: 

Support for knowledge mobilization/engagement/translation, community partnerships, and responsible research assessment (DORA) is available through the Knowledge Engagement Team. Applicants can reach out by email to the KE team at knowledge.engagement@ucalgary.ca. For more information, please visit the KE team webpage. 

Support for Research Data Management: 

For information on research data management plans, processes, or best practices for your research program, please contact research.data@ucalgary.ca OR research.data@ucalgary.libanswers.com. 

Support for EDI in Research: 

RSO can provide resources and support to research teams on the integration of equitable and inclusive practices in research design and research practice. Contact Jaya.Dixit@ucalgary.ca for more information. 

Support for Research Security: 

The Research Security Division is available to assist researchers adhere to research security guidelines and policies, including the National Security Guidelines for Research Partnerships (NSGRP) and the new policy on Sensitive Technology Research and Affiliations of Concern (STRAC). Visit the Research Security website to learn more or contact researchsecurity@ucalgary.ca.  

Reminder: The sooner the researcher engages with RSO units, the more help we can be! 

RMS: Creating a Pre-Award LOI 

RMS: Creating a Pre-Award Application